When the half-life data from the oral formulations was pooled, it was longer than that observed in the IV-Fasted group (100 min) and 35 min, respectively P < 0.0001). No significant differences were present between the ECO-Fasted and ECO-Fed groups with regards to bioavailability, Cmax, Tmax or AUC0-∞. Similarly, AUC0-∞ was higher in the ECO-Fasted group than the PL-Fasted group (P = 0.027).
Bioavailability was higher (P = 0.038) in the ECO-Fasted group (21.5 %) than the PL-Fasted group (10.1 %). Plasma omeprazole concentrations were determined by UHPLC-MS. Twelve horses received four treatments: intravenous omeprazole (0.5 mg/kg) in the fasted state (IV-Fasted), enteric-coated omeprazole (4 mg/kg) orally in the fasted state (ECO-Fasted), enteric-coated omeprazole (4 mg/kg) orally in the fed state (ECO-Fed) and plain omeprazole (4 mg/kg) orally in the fasted state (PL-Fasted). The objectives were to document the pharmacokinetics of intravenous, enteric-coated oral and plain oral omeprazole in fasted horses and to investigate the impact of feeding on the bioavailability of an enteric-coated omeprazole.
0 kommentar(er)
